Study Objectives

Patients are being followed up to a maximum of 5 years and comparison between treatments will be made by assessment of the following criteria:

Primary objective:

  • Overall Survival

Secondary objectives:

  • Progression-free survival (PFS)
  • Liver-specific PFS
  • Objective response rate by RECIST 1.0 (liver ± any site)
  • Safety and tolerability
  • Liver resection / ablation rate
  • Health related quality of life
  • Health economics

Use of Expert Interventional Radiologists

SIRT must only be performed by an interventional radiologist who has been officially trained and credentialed by Sirtex or a duly authorised representative of Sirtex. Sites were encouraged to keep in mind that if they did not possess trained interventional radiology staff, patients could have been referred to an experienced site for the SIRT implantation procedure only. As an additional quality assurance, interventional radiologists who participated in the study were required to have performed at least 10 SIRT cases. Physicians interested in the SIRT training program or are considering starting a program in their institution, please contact a Sirtex representative, either by telephone or through this website.

Site Participation

The FOXFIRE Global study is being conducted at sites across Australia, New Zealand, Asia, Europe, the Middle East and the USA.